Deep learning significantly accelerates the drug discovery process, and contributes to global efforts to stop the spread of infectious diseases. Besides enhancing the efficiency of screening of antimicrobial compounds against a broad spectrum of pathogens, deep learning has also the potential to efficiently and reliably identify drug candidates against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Consequently, deep learning has been successfully used for the identification of a number of potential drugs against SARS-CoV-2, including Atazanavir, Remdesivir, Kaletra, Enalaprilat, Venetoclax, Posaconazole, Daclatasvir, Ombitasvir, Toremifene, Niclosamide, Dexamethasone, Indomethacin, Pralatrexate, Azithromycin, Palmatine, and Sauchinone. This mini-review discusses recent advances and future perspectives of deep learning-based SARS-CoV-2 drug discovery.
【저자키워드】 Drug repurposing, SARS-CoV-2, Drug discovery, deep learning, Antibiotics, database, antimalarial drug, 【초록키워드】 Diseases, Azithromycin, drug, coronavirus 2, Spread, ombitasvir, indomethacin, Pathogens, respiratory, Kaletra, niclosamide, Atazanavir, daclatasvir, Efficiency, Pralatrexate, enalaprilat, Posaconazole, toremifene, Perspective, Compound, drug candidate, deep, identify, significantly, contribute, accelerate, global effort, SARS-CoV-2 drug, 【제목키워드】 drug, coronavirus 2, learning, respiratory, deep,