We reviewed the diagnostic accuracy of SARS-CoV-2 serological tests. Random-effects models yielded a summary sensitivity of 82% for IgM, and 85% for IgG and total antibodies. For specificity, the pooled estimate were 98% for IgM and 99% for IgG and total antibodies. In populations with ≤ 5% of seroconverted individuals, unless the assays have perfect (i.e. 100%) specificity, the positive predictive value would be ≤ 88%. Serological tests should be used for prevalence surveys only in hard-hit areas.
All Keywords
【저자키워드】 Meta-analysis, SARS-CoV-2, systematic review, sensitivity, specificity, Serological tests, predictive values, 【초록키워드】 serological test, IgG, IgM, diagnostic, Population, Prevalence, Positive predictive value, Accuracy, serological, total antibodies, seroconverted, individuals, 【제목키워드】 public health, serological test, diagnostic, SARS-CoV-2 antibody, implication,
【저자키워드】 Meta-analysis, SARS-CoV-2, systematic review, sensitivity, specificity, Serological tests, predictive values, 【초록키워드】 serological test, IgG, IgM, diagnostic, Population, Prevalence, Positive predictive value, Accuracy, serological, total antibodies, seroconverted, individuals, 【제목키워드】 public health, serological test, diagnostic, SARS-CoV-2 antibody, implication,