Background Since the onset of the COVID-19 pandemic, the disease has frequently been compared with seasonal influenza, but this comparison is based on little empirical data. Aim This study compares in-hospital outcomes for patients with community-acquired COVID-19 and patients with community-acquired influenza in Switzerland. Methods This retrospective multi-centre cohort study includes patients > 18 years admitted for COVID-19 or influenza A/B infection determined by RT-PCR. Primary and secondary outcomes were in-hospital mortality and intensive care unit (ICU) admission for patients with COVID-19 or influenza. We used Cox regression (cause-specific and Fine-Gray subdistribution hazard models) to account for time-dependency and competing events with inverse probability weighting to adjust for confounders. Results In 2020, 2,843 patients with COVID-19 from 14 centres were included. Between 2018 and 2020, 1,381 patients with influenza from seven centres were included; 1,722 (61%) of the patients with COVID-19 and 666 (48%) of the patients with influenza were male (p < 0.001). The patients with COVID-19 were younger (median 67 years; interquartile range (IQR): 54–78) than the patients with influenza (median 74 years; IQR: 61–84) (p < 0.001). A larger percentage of patients with COVID-19 (12.8%) than patients with influenza (4.4%) died in hospital (p < 0.001). The final adjusted subdistribution hazard ratio for mortality was 3.01 (95% CI: 2.22–4.09; p < 0.001) for COVID-19 compared with influenza and 2.44 (95% CI: 2.00–3.00, p < 0.001) for ICU admission. Conclusion Community-acquired COVID-19 was associated with worse outcomes compared with community-acquired influenza, as the hazards of ICU admission and in-hospital death were about two-fold to three-fold higher.
【저자키워드】 COVID-19, Mortality, Epidemiology, Influenza, Influenza virus, viral infections, ICU, Surveillance, air-borne infections, Switzerland, clinic, severe acute respiratory syndrome – SARS, 【초록키워드】 intensive care, COVID-19 pandemic, hospital, Infection, outcome, RT-PCR, cohort study, Probability, male, Patient, ICU admission, Admission, in-hospital mortality, retrospective, Cox regression, In-hospital death, In-hospital, Seasonal influenza, interquartile range, hazard ratio, hazard, confounders, secondary outcome, Final, Weighting, event, Seven, Result, died, include, the patient, the disease, median, adjusted, competing, adjust, patients with COVID-19, patients with influenza, subdistribution, with COVID-19, 【제목키워드】 outcome, insight,