The rapid, global spread of the SARS-CoV-2 virus during the current pandemic has triggered numerous efforts in clinical and research settings to better understand the host genetics’ interactions and the severity of COVID-19. Due to the established major role played by MHC/HLA polymorphism in infectious disease course and susceptibility, immunologists and geneticists have teamed up to investigate its contribution to the SARS-CoV-2 infection and COVID-19 progression. A major goal of the Covid-19|HLA & Immunogenetics Consortium is to support and unify these efforts. Here, we present a review of HLA immunogenomics studies in the SARS-CoV-2 pandemic and reflect on the role of various HLA data, their limitation and future perspectives.
【저자키워드】 COVID-19, Immunogenetics, SARS- CoV-2, HLA, MHC, Association analysis, 【초록키워드】 pandemic, susceptibility, Infection, polymorphism, Infectious disease, Spread, severity of COVID-19, Research, Interaction, Support, COVID-19 progression, effort, Host, Course, triggered, the SARS-CoV-2, the SARS-CoV-2 virus, 【제목키워드】 SARS-CoV-2, investigation, current,