The transmembrane serine protease 2 (TMPRSS2) is the major host protease that enables entry of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) into host cells by spike (S) protein priming. Single nucleotide polymorphisms (SNPs) in the gene TMPRSS2 have been associated with susceptibility to and severity of H1N1 or H1N9 influenza A virus infections. Functional variants may influence SARS-CoV-2 infection risk and severity of Coronavirus disease 2019 (COVID-19) as well. Therefore, we analyzed the role of SNPs in the gene TMPRSS2 in a German case-control study. We performed genotyping of the SNPs rs2070788, rs383510, and rs12329760 in the gene TMPRSS2 in 239 SARS-CoV-2-positive and 253 SARS-CoV-2-negative patients. We analyzed the association of the SNPs with susceptibility to SARS-CoV-2 infection and severity of COVID-19. SARS-CoV-2-positive and SARS-CoV-2-negative patients did not differ regarding their demographics. The CC genotype of TMPRSS2 rs383510 was associated with a 1.73-fold increased SARS-CoV-2 infection risk, but was not correlated to severity of COVID-19. Neither TMPRSS2 rs2070788 nor rs12329760 polymorphisms were related to SARS-CoV-2 infection risk or severity of COVID-19. In a multivariable analysis (MVA), the rs383510 CC genotype remained an independent predictor for a 2-fold increased SARS-CoV-2 infection risk. In summary, our report appears to be the first showing that the intron variant rs383510 in the gene TMPRSS2 is associated with an increased risk to SARS-CoV-2 infection in a German cohort.
【저자키워드】 Coronavirus disease 2019, polymorphism, transmembrane serine protease 2, genetic association, rs12329760, Severe acute respiratory syndrome coronavirus type 2, rs383510, rs2070788, 【초록키워드】 COVID-19, SARS-CoV-2, TMPRSS2, coronavirus, SARS-COV-2 infection, susceptibility, severity, SNPs, variant, influenza A virus, risk, Protein, Cohort, infections, Single nucleotide polymorphism, severity of COVID-19, Patient, Genotype, SNP, H1N1, genotyping, patients, case-control study, association, demographics, host cell, acute respiratory syndrome, increased risk, multivariable analysis, transmembrane serine protease, host protease, priming, intron, independent, not differ, analyzed, performed, remained, appear, not correlated, 【제목키워드】 respiratory, serine protease, Type,