ABSTRACT The coronavirus disease 19 (COVID-19) caused by the novel coronavirus known as SARS-CoV-2 has caused a global public health crisis. As of 7 January 2021, 87,640,402 confirmed cases and 1,891,692 mortalities have been reported worldwide. Studies focusing on the epidemiological and clinical characteristics of COVID-19 patients have suggested a dysregulated immune response characterized by lymphopenia and cytokine storm in these patients. The exaggerated immune response induced by the cytokine storm causes septic shock, acute respiratory distress syndrome (ARDS), and/or multiple organs failure, which increases the fatality rate of patients with SARS-CoV-2 infection. Herein, we review the recent research progress on epidemiology, clinical features, and system pathology in COVID-19. Moreover, we summarized the recent therapeutic strategies, which are either approved, under clinical trial, and/or under investigation by the local or global health authorities. We assume that treatments should focus on the use of antiviral drugs in combination with immunomodulators as well as treatment of the underlying comorbidities.
【저자키워드】 COVID-19, SARS-CoV-2, Pathogenesis, Cytokine release syndrome, lymphopenia, ards and multiple organs failure, 【초록키워드】 Treatment, coronavirus disease, pathology, ARDS, Cytokine storm, coronavirus, clinical trial, Mortality, acute respiratory distress syndrome, Clinical characteristics, Epidemiology, SARS-COV-2 infection, antiviral drugs, Infection, Comorbidities, Local, cytokine, Clinical features, antiviral drug, Health crisis, Novel coronavirus, immunomodulator, lymphopenia, immunomodulators, Research, Therapeutic strategies, Septic shock, epidemiological, patients, acute respiratory distress, Combination, COVID-19 patient, focus, respiratory distress, health authorities, confirmed case, global public health, syndrome, Fatality rate, dysregulated immune response, exaggerated immune response, caused, reported, approved, characterized, increase, suggested, cause, multiple organ, patients with SARS-CoV-2, the cytokine storm, 【제목키워드】 pathology, dysregulation,