The COVID-19 pandemic is a global health crisis that requires the application of interdisciplinary research to address numerous knowledge gaps including molecular strategies to prevent viral reproduction in affected individuals. In response to the Frontiers Research Topic, “ Coronavirus disease (COVID-19): Pathophysiology, Epidemiology, Clinical Management, and Public Health Response ,” this Hypothesis article proposes a novel therapeutic strategy to repurpose metabotropic glutamate 5 receptor (mGluR 5 ) inhibitors to interfere with viral hijacking of the host protein synthesis machinery. We review pertinent background on SARS-CoV-2, fragile X syndrome (FXS) and metabotropic glutamate receptor 5 (mGluR 5 ) and provide a mechanistic-based hypothesis and preliminary data to support testing mGluR 5 inhibitors in COVID-19 research.
【저자키워드】 COVID-19, coronavirus, protein synthesis, fragile X mental retardation protein, metabotropic glutamate receptor 5, 【초록키워드】 SARS-CoV-2, knowledge, COVID-19 pandemic, Health, clinical, response, Research, receptor, molecular, inhibitor, disease, therapeutic strategy, Glutamate, Hypothesis, Support, syndrome, host protein, Preliminary data, COVID-19 research, Public, Prevent, affected, interfere, individuals, 【제목키워드】 SARS-CoV-2, repurposing, drug, reproduction,