Background: Despite the pandemic, data are limited regarding COVID-19 infection in pregnant women and newborns. This report aimed to bring new information about presentation that could modify precautionary measures for infants born of mothers with a remote history of COVID-19. Methods: We report two infants with possible maternofetal transmission, and four mothers without immunologic reactions. Data were collected from the patient files. Results: One mother exhibited infection signs 10 days before uncomplicated delivery, with negative RT-PCR and no antibody detection thereafter. Another mother exhibited infection 6 weeks pre-delivery, confirmed by nasopharyngeal swab testing with positive RT-PCR, and positive antibody detection (IgM and IgG). Both newborns were asymptomatic but tested positive for nasopharyngeal and stool RT-PCR at 1 and 3 days of age for the first one and at 1 day of age for stool analysis for the second one. Two additional mothers exhibited infection confirmed by positive RT-PCR testing at 28- and 31-days pre-delivery but did not present detectable antibody reaction at the time of delivery. Conclusion: These observations raise concerns regarding contamination risk by asymptomatic newborns and the efficacy of immunologic reactions in pregnant mothers, questioning the reliability of antibody testing during pregnancy.
【저자키워드】 COVID-19, antibodies, Case report, Newborn, Pregnancy, vertical transmission, 【초록키워드】 Efficacy, Antibody testing, pandemic, reliability, antibody, Infection, risk, Transmission, RT-PCR, Infant, pregnant women, Nasopharyngeal swab, Stool, Contamination, Antibody detection, Asymptomatic, COVID-19 infection, nasopharyngeal, age, information, mother, positive RT-PCR, pregnant, Analysis, IgM and IgG, observation, Reactions, reaction, measure, positive, negative RT-PCR, raise, tested, collected, the patient, detectable, exhibited, modify, 【제목키워드】 SARS-CoV-2, intrapartum, Sery,