Background: It has been suggested that children and infants can develop multisystem inflammatory syndrome in children (MIS-C) in response to a SARS-CoV-2 infection and that Black children are overrepresented among cases. The aim of the current study was to quantify the association between Black, Asian, or other non-White genetic background and COVID-19-related MIS-C in children and infants. Methods: Eight different research groups contributed cases of MIS-C, potentially related to SARS-CoV-2 infection. Several sensitivity analyses were performed, including additional data available from the literature. Analyses were stratified by geographical region. Results: Seventy-three cases from nine distinct geographical regions were included in the primary analyses. In comparison to White children, the relative risk for developing MIS-C after SARS-CoV-2 infection was 15 [95% confidence interval (CI): 7.1 to 32] for Black children, 11 (CI: 2.2 to 57) for Asian, and 1.6 (CI: 0.58 to 4.2) for other ethnic background. Conclusion: Pediatricians should be aware of the fact that the risk of COVID-19-related MIS-C is severely increased in Black children.
【저자키워드】 COVID-19, SARS-CoV2, MIS-C, Ethnicity, PIMS, 【초록키워드】 SARS-COV-2 infection, children, risk, Infant, Infants, Research, sensitivity analysis, group, association, Inflammatory, Asian, black, confidence interval, syndrome, white, geographical region, genetic background, performed, develop, nine, suggested, contributed, analyses, stratified, Pediatrician, 【제목키워드】 SARS-CoV-2,