In December 2019, the first case of coronavirus disease (COVID-19) was first reported in Wuhan, China. As of March 2021, there were more than 120 million confirmed cases of COVID-19 and 2.7 million deaths. The COVID-19 mortality rate in adults is around 1–5%, and only a small proportion of children requires hospitalization and intensive care. Recently, an increasing number of COVID-19 cases in children have been associated with a new multisystem inflammatory syndrome. Its clinical features and laboratory characteristics are similar to those of Kawasaki disease (KD), KD shock syndrome, and toxic shock syndrome. However, this new disorder has some distinct clinical features and laboratory characteristics. This condition, also known as multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, has been observed mostly in Europe and the United States. This emerging phenomenon has raised the question of whether this disorder is KD triggered by SARS-CoV-2 or a syndrome characterized by multisystem inflammation that mimics KD. This narrative review is to discuss the differences between MIS-C and KD with the aim of increasing pediatricians’ awareness of this new condition and guide them in the process of differential diagnosis.
【저자키워드】 Coronavirus disease 2019, multisystem inflammatory syndrome in children, Kawasaki disease, pediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2, difference, 【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, Inflammation, Europe, intensive care, Hospitalization, children, MIS-C, Shock, laboratory characteristics, differential diagnosis, clinical feature, Inflammatory, COVID-19 mortality, deaths, confirmed case, COVID-19 case, syndrome, disorder, The United States, Wuhan, China, proportion, reported, raised, characterized, question, triggered, with COVID-19,