Introduction: COVID-19 is associated with a novel multi-system inflammatory syndrome that shares some characteristics with Kawasaki’s Disease. The syndrome manifestation is delayed relative to COVID-19 onset, with a spectrum of clinical severity. Clinical signs may include persistent fever, gastrointestinal symptoms, cardiac inflammation and/or shock. Case Presentation: We measured 59 inflammatory and endothelial injury plasma analytes in an adolescent girl that presented with malaise, fever, cough, strawberry tongue and jaundice. Her COVID-19 status was positive with detection of 2 SARS-CoV-2 viral genes using polymerase chain reaction. She was treated with intravenous immunoglobulin prior to blood draw, but our plasma measurements suggested a unique analyte expression pattern associated with inflammation, endothelial injury and microvascular glycocalyx degradation. Conclusions: COVID-19 is associated with a multi-system inflammatory syndrome and a unique inflammatory and endothelial injury signature. Summary: Analyte markers of inflammation and endothelial cell injury might serve as putative biomarkers and/or be investigated further as potential therapeutic targets.
【저자키워드】 COVID-19, Inflammation, children, MIS-C, endothelial injury, multisystem, 【초록키워드】 Intravenous immunoglobulin, Biomarker, cough, Shock, Characteristics, Fever, plasma, Degradation, tongue, marker, Endothelial cell, Clinical severity, gastrointestinal symptoms, Inflammatory, Injury, syndrome, malaise, potential therapeutic targets, analyte, positive, jaundice, expression pattern, Clinical sign, blood draw, polymerase chain, SARS-CoV-2 viral, include, investigated, treated, unique, suggested, 【제목키워드】 Profiling,