Introduction Different factors are critical when assessing COVID-19 mortality, and can explain why severity differs so widely among populations. However, there is little information regarding prognostic factors and mortality in COVID-19 from Latin American countries. Objectives To determine prognostic factors in hospitalized COVID-19 patients and to evaluate the impact of tocilizumab use in patients with hyperinflammatory syndrome and severe disease defined by the National Early Warning Score 2 (NEWS2) with a value greater than or equal to seven points. Materials and methods This retrospective cohort study included hospitalized COVID-19 patients from May to July 2020. A multivariate logistic regression analysis was performed to determine independent factors associated with mortality. Results A total of 136 patients required hospital admission. In-hospital mortality was 39.7%. Mortality was observed to be potentiated by older age, LDH serum levels and the presence of type 2 diabetes mellitus. Lymphopenia and lower PaO2/FiO2 ratio were more common in these patients. Similarly, patients who died were classified more frequently with severe disease. The independent factors associated with in-hospital mortality were age greater than 65 years, type 2 diabetes mellitus, NEWS2 greater than or equal to seven points and LDH greater than 400U/L. The use of Tocilizumab alone was not related with decreased in-hospital mortality. Subgroup analysis performed in patients with hyperinflammation and severe disease showed similar results. Conclusions COVID-19 mortality in hospitalized patients was high and mainly related with older age, comorbidities, LDH and the severity of disease at hospital admission.
【저자키워드】 COVID-19, SARS CoV-2, Tocilizumab, disease mortality, covid prognosis, 【초록키워드】 Mortality, severity, Comorbidities, LDH, serum, Hyperinflammatory syndrome, hyperinflammation, Patient, Older age, age, Hospital admission, Severity of disease, information, Critical, patients, score, in-hospital mortality, hospitalized COVID-19 patient, Analysis, COVID-19 mortality, severe disease, Prognostic factor, NEWS2, retrospective cohort study, Factor, multivariate logistic regression, PaO2/FiO2 ratio, material, objective, populations, independent, Seven, Result, greater, defined, performed, evaluate, died, required, was performed, determine, hospitalized patient, explain, Latin, type 2 diabete, 【제목키워드】 Factor,