Early detection of severe forms of COVID-19 is absolutely essential for timely triage of patients. We longitudinally followed-up two well-characterized patient groups, hospitalized moderate to severe (n = 26), and ambulatory mild COVID-19 patients (n = 16) at home quarantine. Human D-dimer, C-reactive protein (CRP), ferritin, cardiac troponin I, interleukin-6 (IL-6) levels were measured on day 1, day 7, day 14 and day 28. All hospitalized patients were SARS-CoV-2 positive on admission, while all ambulatory patients were SARS-CoV-2 positive at recruitment. Hospitalized patients had higher D-dimer, CRP and ferritin, cardiac troponin I and IL-6 levels than ambulatory patients ( p < 0.001, p < 0.001, p = 0.016, p = 0.035, p = 0.002 respectively). Hospitalized patients experienced significant decreases in CRP, ferritin and IL-6 levels from admission to recovery ( p < 0.001, p = 0.025, and p = 0.001 respectively). Cardiac troponin I levels were high during the acute phase in both hospitalized and ambulatory patients, indicating a potential myocardial injury. In summary, D-dimer, CRP, ferritin, cardiac troponin I, IL-6 are predictive laboratory markers and can largely determine the clinical course of COVID-19, in particular the prognosis of critically ill COVID-19 patients.
【저자키워드】 Diagnostic markers, Prognostic markers, Predictive markers, 【초록키워드】 COVID-19, SARS-CoV-2, Hospitalized, Prognosis, IL-6, Human, interleukin-6, C-reactive protein, CRP, D-dimer, ferritin, hospitalized patients, Laboratory, cardiac troponin, Clinical course, myocardial injury, interleukin, Critically ill, Early detection, Patient, troponin I, recruitment, Admission, moderate, patients, COVID-19 patients, marker, Cardiac troponin I, cardiac, home quarantine, critically ill COVID-19 patients, IL-6 levels, on admission, Predictive, moderate to severe, ambulatory patients, acute phase, patient groups, significant decrease, severe forms of COVID-19, positive, form, determine, hospitalized patient, were measured, ambulatory patient, IL-6 level, mild COVID-19 patient, 【제목키워드】 Hospitalized, Laboratory, longitudinal, marker, COVID-19 patient,