Introduction: COVID-19 vaccines have been found to be efficacious for preventing severe disease, yet breakthrough infections and deaths have occurred in a small proportion of vaccinated individuals. This study aimed to describe the vaccination status and comorbidities of COVID-19 all-cause deaths. Methods: This descriptive observational study was conducted at a tertiary care center in western India. A total of 310, RT-PCR positive COVID-19 deaths, aged 45 years and above irrespective of the cause of death (all-cause mortality), were included in the study. Death after breakthrough infection was defined as death in patient with disease onset after 14 days of the second dose of vaccine. Results: Diabetes was the most common comorbidity found in 17.1% of the deaths, followed by hypertension. Cardiovascular disease and renal disease were other common comorbidities seen in 8.7% and 4.83% deaths respectively. Other less common comorbidities include neurological disorders, HIV, autoimmune disorders. Out of these 310 deaths, 21.4% of patients developed disease within 14 days of the first dose. Death after true breakthrough infection (after 14 days of both doses) was seen in only two patients (0.6%). One of these two patients was aged 60 years and had diabetes, while the other was aged 72 years and had a history of smoking. Conclusion: Diabetes and hypertension were the most common comorbidities, indicating a higher risk of mortality among comorbid patients. Only a small proportion of deaths (0.6%) occurred after breakthrough infection beyond 14 days of two doses. COVID-19 vaccines have shown promising efficacy against severe disease, thus high vaccination coverage needs to be achieved to prevent morbidity and mortality.
【저자키워드】 COVID, Corona, Breakthrough infection, Covaxin, Covishield, 【초록키워드】 COVID-19, HIV, Efficacy, Vaccine, COVID-19 vaccine, vaccination, Mortality, India, Comorbidities, Comorbidity, diabetes, smoking, RT-PCR, hypertension, cardiovascular, Coverage, Patient, death, morbidity and mortality, Neurological disorders, Other, disease, Care, Autoimmune disorders, severe disease, deaths, disease onset, higher risk, second dose, first dose, all-cause mortality, vaccinated individuals, doses, renal, positive COVID-19, Prevent, defined, shown, occurred, include, proportion, conducted, less, comorbid patients, 【제목키워드】 COVID-19, India, status, center, Tertiary,