Background and aims: Favipiravir is a ribonucleic acid (RNA)-dependent RNA polymerase (RdRP) inhibitor antiviral agent used in the treatment of coronavirus disease-2019 (COVID-19). In this study, we investigated the changes in serum transaminase levels of patients and the relationship between serum transaminase elevation with mortality in patients who were hospitalized with the diagnosis of COVID-19 and received favipiravir treatment. Materials and methods: 454 patients who received favipiravir and 113 patients who did not receive favipiravir were evaluated. Serum transaminase levels of the patients were compared at baseline and after five days of treatment, and the relationship between serum transaminase elevation and mortality was investigated. Results: No significant aspartate aminotransferase (AST) or alanine aminotransferase (ALT) elevation was detected due to favipiravir treatment. AST elevation was found, respectively, as 133 (29.3%), 32 (28.3%) (p=0.100), ALT elevation as 112 (24.7%), 35 (29.3%) (p=0.100) in the groups receiving and not receiving favipiravir. High AST level was found as a risk factor for mortality in all patient groups (p=0.008). Conclusions: There was no statistically significant elevation in serum transaminase levels due to favipiravir use in patients hospitalized for COVID-19. A high level of AST is a significant risk factor to show mortality and intensive care unit (ICU) admission in patients with COVID-19.
【저자키워드】 COVID-19, Mortality, Favipiravir, ICU admission, elevated transaminases, 【초록키워드】 Treatment, Hospitalized, intensive care, Antiviral, risk factor, ICU, Patient, Aspartate aminotransferase, AST, RNA polymerase, group, inhibitor, Admission, ALT, alanine aminotransferase, material, FIVE, the patient, investigated, evaluated, receiving, changes in, statistically significant, receive, 113 patient, baseline, diagnosis of COVID-19, patients hospitalized, patients with COVID-19, serum transaminase, 【제목키워드】 Elevation, transaminase, Level,