We present the case of a nine-month-old male child with three days of fever, irritability, left focal seizure, and febrile focal status epilepticus. He had no history of previous comorbidities. A lumbar puncture was performed, which showed cerebrospinal fluid (CSF) leukocytosis; protein and glucose were normal, and the polymerase chain reaction (PCR) panel for 14 pathogens in CSF was negative. Immunoglobulin G (IgG) qualitative and quantitative tests were positive for coronavirus disease 2019 (COVID-19) upon arrival. An MRI performed one week after the initial onset showed findings suggestive of acute necrotizing encephalopathy (ANE). The patient required mechanical ventilation. However, his symptoms did not improve and follow-up imaging two weeks later showed progression of the disease with hemorrhagic changes. To our knowledge, this is the first reported case of ANE associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a pediatric patient.
【저자키워드】 COVID-19, SARS CoV-2, Child, acute necrotizing encephalitis, 【초록키워드】 coronavirus disease, IgG, coronavirus, mechanical ventilation, knowledge, pediatric, Infection, Comorbidities, Symptom, progression, MRI, Protein, PCR, pathogen, Fever, male, Patient, Encephalopathy, Follow-up, cerebrospinal fluid, quantitative test, Glucose, CSF, Seizure, changes, Hemorrhagic, acute respiratory syndrome, positive, irritability, polymerase chain, initial, IMPROVE, performed, reported, the disease, required, was performed, had no, 【제목키워드】 SARS-CoV-2, exposure,