Chlorpheniramine maleate, a widely used over-the-counter antihistamine, has been identified as a structural analog of aminoquinolines known to possess antiviral activity against the Betacoronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19). Structural similarities include the chlorophenyl group, pyridine ring, alkyl sidechain, and terminal tertiary amine; the comparison of aqueous energy-minimized structures indicates significant three-dimensional similarity as well. Preliminary clinical evidence supports these conclusions. The present study suggests that chlorpheniramine possesses antiviral activity against COVID-19.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, Molecular modeling, Clinical findings, Antiviral agents, chlorpheniramine maleate, 【초록키워드】 coronavirus disease, Structure, antiviral activity, Coronavirus-2, similarity, Support, acute respiratory syndrome, clinical evidence, include, indicate, cause, Chlorpheniramine, the Betacoronavirus, 【제목키워드】 activity, clinical, modeling, Against, Chlorphenamine, Chlorpheniramine,
【저자키워드】 COVID-19, SARS-CoV-2, Molecular modeling, Clinical findings, Antiviral agents, chlorpheniramine maleate, 【초록키워드】 coronavirus disease, Structure, antiviral activity, Coronavirus-2, similarity, Support, acute respiratory syndrome, clinical evidence, include, indicate, cause, Chlorpheniramine, the Betacoronavirus, 【제목키워드】 activity, clinical, modeling, Against, Chlorphenamine, Chlorpheniramine,