Introduction Coronavirus disease 2019 (COVID-19) affects various organs including lungs, brain, and eyes. Very limited data is available related to the effect of COVID-19 on liver. This study is conducted to determine the impact of COVID-10 on liver by measuring the frequency of participants with deranged liver enzymes in patients diagnosed with COVID-19. Methods This cross-sectional study was conducted in a COVID-19 unit of a tertiary care hospital in Pakistan from February 2021 to June 2021. A total of 900 patients admitted with COVID-19 were enrolled in the study after seeking informed consent. After enrollment, taking history and vitals, 5 mL blood was drawn via phlebotomy and sent to the laboratory to test for C-reactive protein, lactate dehydrogenase, and liver enzymes. Results Overall 141 (28.2%) participants had a minimum of one deranged liver enzyme. The most commonly deranged liver enzyme found was alanine transaminase (ALT), both in males (19.9%) and females (21.3%), followed by aspartate transaminase (male: 18.3% and female: 20.3%). Serum total bilirubin was deranged in both males (8.4%) and females (8.3%). There was no significant difference in the gender-wise prevalence of deranged liver enzymes. Conclusion Liver enzymes are frequently deranged in patients admitted with COVID-19. Liver enzymes should be regularly monitored during the course of management of COVID-19, as various medications used in the treatment of COVID-19 may further deteriorate liver enzymes and may cause long-term damage.
【저자키워드】 COVID-19, novel corona virus, liver enzymes, sars-cov-2 (severe acute respiratory syndrome coronavirus -2), hepatic enzymes, 【초록키워드】 Treatment, Coronavirus disease 2019, cross-sectional, hospital, C-reactive protein, lactate dehydrogenase, Brain, Laboratory, Prevalence, management, Lungs, male, female, Patient, medication, Care, liver, Blood, ALT, Frequency, liver enzyme, Enrollment, total bilirubin, no significant difference, enzyme, Alanine, Aspartate transaminase, participant, eyes, organ, Affect, vitals, Course, Result, enrolled, conducted, determine, COVID-10, deteriorate, diagnosed with COVID-19, seeking, with COVID-19, 【제목키워드】 Impact,