Approximately one-third of infected pregnant women died from severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) epidemics of the past two decades. It is logical to predict that pregnant women infected with the novel coronavirus (SARS-CoV-2) might be at higher risk for severe illness, morbidity, or mortality compared with non-pregnant women. However, a review of the literature indicates that pregnant women are not more likely to be seriously ill than other healthy non-pregnant women if they develop coronavirus disease (COVID-19). This observation begs the question: “Why does pregnancy not increase the risk for acquiring SARS-CoV-2 infection, nor does it worsen the clinical course of COVID-19 compared with non-pregnant individuals?” Herein, we try to explain our observations when considering whether the immunologic changes of pregnancy and other physiologic adaptations of pregnancy affect the virulence and course of SARS-CoV-2 infection.
【저자키워드】 COVID-19, Adaptive immunity, ARDS, Clinical features, Cell-mediated immunity, COVID-19 in pregnancy, better outcomes, human pathophysiology, complications’, 【초록키워드】 coronavirus disease, SARS-CoV-2, coronavirus, Mortality, SARS-CoV, SARS-COV-2 infection, Epidemics, risk, MERS-CoV, Novel coronavirus, pregnant women, Clinical course, Pregnancy, morbidity, women, virulence, predict, Middle East, observation, acute respiratory syndrome, higher risk, respiratory syndrome coronavirus, Affect, Course, develop, died, healthy, indicate, explain, immunologic change,