Recent studies have suggested the neuroinvasive potential of severe acute respiratory coronavirus 2 (SARS-CoV-2). Notably, neuroinvasiveness might be involved in the pathophysiology of coronavirus disease 2019 (COVID-19). Some studies have demonstrated that synapse-connected routes may enable coronaviruses to access the central nervous system (CNS). However, evidence related to the presence of SARS-CoV-2 in the CNS, its direct impact on the CNS, and the contribution to symptoms suffered, remain sparse. Here, we review the current literature that indicates that SARS-CoV-2 can invade the nervous system. We also describe the neural circuits that are potentially affected by the virus and their possible role in the progress of COVID-19. In addition, we propose several strategies to understand, diagnose, and treat the neurological symptoms of COVID-19.
【저자키워드】 COVID-19, SARS-CoV-2, Anosmia, dysgeusia, Central nervous system, Peripheral nervous system, 【초록키워드】 coronavirus disease, coronavirus, Symptom, virus, pathophysiology, nervous system, CNS, diagnose, Evidence, Neuroinvasive, treat, recent, Respiratory Coronavirus, Neurological symptom, affected, involved, addition, indicate, demonstrated, suggested, suffered, 【제목키워드】 review,