Angiotensin-converting enzyme II (ACE2) in association with type II transmembrane serine protease (TMPRSS2) is considered the main receptor of SARS-CoV-2. However, considering the clinical complications of COVID-19 in different organs, there is no strong association between the abundance of ACE2/TMPRSS2 co-expression and clinical features of the disease and the severity of complications. Since SARS-CoV-2 affects certain organs that lack or have low expression of ACE2/TMPRSS2, it may be possible that the virus employs other receptors for colonization and entry. Based on recent studies, glucose-regulated protein 78 (GRP78) can be a potential alternative receptor for SARS-CoV-2 entry. In this letter, supporting evidence proposed GRP78 as an alternative receptor in SARS-CoV-2 infection.
【저자키워드】 COVID-19, SARS-CoV-2, endoplasmic reticulum stress, HSPA5, Angiotensin-converting enzyme II, TMPRSS2, 【초록키워드】 ACE2, SARS-COV-2 infection, severity, virus, GRP78, Protein, complications, receptor, clinical feature, association, Evidence, SARS-CoV-2 entry, low expression, transmembrane serine protease, organs, organ, main receptor, Affect, co-expression, clinical complication, lack, the disease, enzyme II,