(1) Background: Healthcare workers (HCWs) are prone to intensified exposure to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in the ongoing pandemic. We prospectively analyzed the prevalence of antibodies against SARS-CoV-2 in HCWs at baseline and follow up with regard to clinical signs and symptoms in two university hospitals in Brandenburg, Germany. (2) Methods: Screening for anti-SARS-CoV-2 IgA and IgG antibodies was offered to HCWs at baseline and follow up two months thereafter in two hospitals of Brandenburg Medical School during the first wave of the COVID-19 pandemic in Germany in an ongoing observational cohort study. Medical history and signs and symptoms were recorded by questionnaires and analyzed. (3) Results: Baseline seroprevalence of anti-SARS-CoV-2 IgA was 11.7% and increased to 15% at follow up, whereas IgG seropositivity was 2.1% at baseline and 2.2% at follow up. The rate of asymptomatic seropositive cases was 39.5%. Symptoms were not associated with general seropositivity for anti-SARS-CoV-2; however, class switch from IgA to IgG was associated with increased symptom burden. (4) Conclusions: The seroprevalence of antibodies against SARS-CoV-2 was low in HCWs but higher compared to population data and increased over time. Screening for antibodies detected a significant proportion of seropositive participants cases without symptoms.
【저자키워드】 COVID-19, SARS-CoV-2, Healthcare workers, Seroprevalence, Symptoms, Germany, First wave, IgG response, anti-SARS-CoV-2 IgA, 【초록키워드】 IgG, pandemic, antibody, COVID-19 pandemic, hospital, Infection, Symptom, anti-SARS-CoV-2, healthcare worker, Screening, Prevalence, IgG antibody, Asymptomatic, HCWs, IgA, School, questionnaire, seropositive, Coronavirus-2, HCW, medical history, Observational cohort study, acute respiratory syndrome, symptom burden, university hospital, Clinical sign, analyzed, proportion, were recorded, baseline, offered, seropositive participant, without symptoms, 【제목키워드】 IgG, IgA, Wave, worker, Result, Interim,