Since the spread of COVID-19, pediatric patients were initially considered less affected by SARS-COV-2, but current literature reported subsets of children with multisystem inflammatory syndrome (MIS-C). This study aims to describe the cardiac manifestation of SARS-COV-2 infection in a large cohort of children admitted to two Italian pediatric referral centers. Between March 2020 and March 2021, we performed a cardiac evaluation in 294 children (mean age 9 ± 5.9 years, male 60%) with active or previous SARS-COV-2 infection. Twenty-six showed ECG abnormalities: 63 repolarization anomalies, 13 Long QTc, five premature ventricular beats, two non-sustained ventricular tachycardia, and one atrial fibrillation. In total, 146 patients underwent cardiac biomarkers: NT-proBNP was elevated in 57, troponin in 34. An echocardiogram was performed in 98, showing 54 cardiac anomalies: 27 left-ventricular dysfunction, 42 pericarditis, 16 coronaritis. MIS-C was documented in 46 patients (mean age 9 ± 4.8 years, male 61%) with cardiac manifestations in 97.8%: 27 ventricular dysfunctions, 32 pericarditis, 15 coronaritis, 3 arrhythmias. All patients recovered, and during follow-up, no cardiac anomalies were recorded. Our experience showed that cardiac involvement is not rare in children with SARS-COV-2, and occurred in almost all patients with MIS-C. However, patients’ recovery is satisfactory and no additional events were reported during FU.
【저자키워드】 COVID-19, SARS-CoV-2, children, MIS-C, myocarditis, cardiac involvement, 【초록키워드】 pediatric, Infection, ECG, Atrial fibrillation, male, Patient, age, Premature, large cohort, Follow-up, NT-proBNP, Arrhythmias, QTc, Inflammatory, manifestation, dysfunction, Tachycardia, Echocardiogram, Pediatric patient, syndrome, anomalies, FIVE, Italian, event, Long, spread of COVID-19, performed, affected, occurred, reported, elevated, was performed, less, subset, were recorded, cardiac anomaly, ventricular, 【제목키워드】 experience, cardiac, manifestation,