Background: This study aimed to explore the predictive value of a clinical biochemistry-based nomogram in COVID-19. Methods: The plasma or serum concentrations/levels of carcinoembryonic antigen (CEA) and other biomarkers, e.g., C-reactive protein (CRP), white blood cell (WBC), interleukin-6 (IL-6), ferritin (Fer), procalcitonin (PCT), lymphocyte percentage (L%), D-dimer (D2), and neutrophils percentage (Neu%), were assessed in 314 hospitalized patients with confirmed COVID-19. The area under the curve was used to estimate the diagnostic and prognostic value for COVID-19. Cox and logistic regression analyses were used to estimate the independent prognostic risk factors for the survival of patients with COVID-19. Results: Receiver operating characteristic (ROC) curves were used to determine the area under the curve (AUC) values for CEA, IL-6, CRP, PCT, Fer, D-dimer levels and L%, Neu%, and WBC to assess disease classification. The critical values for these markers to predict severe disease type were then determined. The hazard ratio of prognosis for risk of COVID-19 identified CEA, WBC, CRP, PCT, Fer, D-dimer, Neu%, and L% as independent prognostic factors. For the nomogram of overall survival (OS), the C-index was 0.84, demonstrating a good discriminative performance. Conclusions: An OS nomogram for the clinical diagnosis and treatment of COVID-19 was constructed using biomarkers. These data will be useful for the diagnosis, management, and therapy of COVID-19.
【저자키워드】 Coronavirus disease 2019, Prognosis, inflammatory markers, Carcinoembryonic antigen, hazard ratio, 【초록키워드】 COVID-19, Treatment, therapy, Biomarkers, IL-6, neutrophil, diagnostic, interleukin-6, Diagnosis, C-reactive protein, CRP, D-dimer, ferritin, procalcitonin, risk factor, Antigen, lymphocyte, serum, survival, ROC, White blood cell, management, Prognostic factors, Logistic regression, plasma, WBC, prognostic, disease, Clinical diagnosis, Critical, predict, marker, D-dimer level, Analysis, severe disease, AUC, Predictive, receiver operating characteristic, Prognostic value, C-index, risk of COVID-19, PCT, independent, was used, were used, determine, hospitalized patient, CEA, patients with COVID-19, were assessed, 【제목키워드】 nomogram, clinical, value,