Objectives: An outbreak of coronavirus disease (COVID-19) in 2019 in Wuhan, China, has spread quickly worldwide. However, the risk factors associated with COVID-19-related mortality remain controversial. Methods: A total of 245 adult patients with laboratory-confirmed COVID-19 from two centers were analyzed. Chi-square, Fisher’s exact, and the Mann-Whitney U -tests were used to compare the clinical characteristics between the survivors and non-survivors. To explore the risk factors associated with in-hospital death, univariable and multivariable cox regression analyses were used. Results: Of the 245 patients included in this study, 23 (9.4%) died in the hospital. The multivariate regression analysis showed increased odds of in-hospital deaths associated with age, D-dimer levels >1,000 ng/L, platelet count <125, and higher serum creatinine levels. Conclusions: We identified risk factors that show significant association with mortality in adult COVID-19 patients, and our findings provide valuable references for clinicians to identify high-risk patients with COVID-19 at an early stage.
【저자키워드】 COVID-19, SARS-CoV-2, Risk factors, Mortality, Wuhan, 【초록키워드】 coronavirus disease, Clinical characteristics, hospital, risk factor, Spread, outbreak, Patient, Platelet, age, early stage, association, D-dimer level, In-hospital death, regression analysis, serum creatinine, Non-survivors, clinician, adult COVID-19 patients, Chi-square, laboratory-confirmed, Fisher, survivor, Mann-Whitney U, high-risk patient, Wuhan, China, multivariable, analyzed, identify, died, were used, regression analysis, univariable, with COVID-19, 【제목키워드】 multicenter study, Factor,