Little literature exists about critically ill patients with coronavirus disease 2019 (COVID-19) from Latin America. Here, we aimed to describe the clinical characteristics and mortality risk factors in mechanically ventilated COVID-19 patients from Mexico. For this purpose, we recruited 67 consecutive mechanically ventilated COVID-19 patients which were grouped according to their clinical outcome (survival vs. death). Clinical risk factors for mortality were identified by machine-learning and logistic regression models. The median age of participants was 42 years and 65% were men. The most common comorbidity observed was obesity (49.2%). Fever was the most frequent symptom of illness (88%), followed by dyspnea (84%). Multilobe ground-glass opacities were observed in 76% of patients by thoracic computed tomography (CT) scan. Fifty-two percent of study participants were ventilated in prone position, and 59% required cardiovascular support with norepinephrine. Furthermore, 49% of participants were coinfected with a second pathogen. Two-thirds of COVID-19 patients developed acute kidney injury (AKIN). The mortality of our cohort was 44.7%. AKIN, uric acid, lactate dehydrogenase (LDH), and a longitudinal increase in the ventilatory ratio were associated with mortality. Baseline PaO2/FiO2 values and a longitudinal recovery of lymphocytes were protective factors against mortality. Our study provides reference data about the clinical phenotype and risk factors for mortality in mechanically ventilated Mexican patients with COVID-19.
【저자키워드】 COVID-19, SARS-CoV-2, ARDS, Risk factors, Mortality, 【초록키워드】 coronavirus disease, Prone position, Clinical characteristics, obesity, LDH, Comorbidity, Acute kidney injury, Symptom, risk factor, lactate dehydrogenase, Clinical outcome, Computed tomography, lymphocyte, ground-glass opacity, Cohort, survival, pathogen, Latin America, clinical, Dyspnea, Patient, death, machine-learning, clinical phenotype, mortality risk factor, Thoracic, COVID-19 patient, uric acid, Support, Critically ill patient, paO2/fiO2, Ventilated, median age, protective factor, participant, ventilatory, mechanically ventilated, logistic regression models, men, recruited, required, provide, increase in, study participant, patients with COVID-19, 【제목키워드】 clinical, Factor, Ill,