Since the appearance of the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003 in China, diabetes mellitus (DM) and hyperglycemia in patients infected with SARS-CoV, represent independent predictors of mortality. Therefore, metabolic control has played a major role in the prognosis of these patients. In the current pandemic of coronavirus disease 19 (COVID-19), multiple studies have shown that DM is one of the main comorbidities associated with COVID-19 and higher risk of complications and death. The incidence and prevalence of COVID-19 complications and death related with hyperglycemia in patients with or without DM are high. There are many hypotheses related with worse prognosis and death related to COVID-19 and/or hyperglycemia. However, the information about the interplay between hyperglycemia and angiotensin-converting enzyme 2 (ACE2), the critical receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in the context of SARS-CoV-2 infection, is almost null, but there is enough information to consider the possible participation of hyperglycemia in the glycation of this protein, unleashing a pool of reactions leading to acute respiratory distress syndrome and death in patients with COVID-19. In this document we investigated the current evidence related with ACE2 as a key element within the pathophysiological mechanism related with hyperglycemia extrapolating it to context of SARS-CoV-2 infection and its relationship with worse prognosis and death for COVID-19.
【저자키워드】 COVID-19, SARS-CoV-2, hyperglycemia, ACE2 glycation, non-enzymatic glycation, 【초록키워드】 coronavirus disease, ACE2, coronavirus, pandemic, Mortality, Prognosis, SARS-CoV, SARS-COV-2 infection, Diabetes Mellitus, Comorbidity, angiotensin-converting enzyme 2, China, Protein, Patient, death, Complication, receptor, incidence, information, Critical, patients, acute respiratory distress, Evidence, acute respiratory syndrome, higher risk, reaction, syndrome, worse prognosis, pathophysiological mechanism, shown, investigated, hypothese, multiple study, independent predictor, patients with COVID-19, prevalence of COVID-19, with COVID-19, 【제목키워드】 pulmonary, function, Context,