Objectives: The 2019 novel coronavirus disease (COVID-19) pandemic is the biggest public health crises in the 21st century. While most patients infected with the COVID-19 virus have no to moderate symptoms, there is currently limited clinical information about these patients. Methods: In this study, we retrospectively investigated 41 patients infected with the COVID-19 virus in Nanchang, Jiangxi province, China, from February 4 to March 2, 2020. Nanchang is about 260 km southeast of Wuhan, the initial epicenter of the COVID-19 pandemic. We retrieved information on patient demographics, physical examination results, epidemiology, clinical manifestations, underlying conditions, laboratory analyses, radiological images, and treatment outcomes. Results: Most patients (70.7%) had a history of close contact with patients with confirmed COVID-19, and 16 patients (39.0%) showed a high degree of family clustering. All 41 patients had no to moderate symptoms. The median age was 39.9 years and common symptoms of illness were fever (69.2%), cough (65.4%), and fatigue (19.2%). The dominant patient group was middle-aged women, with hypertension (14.6%) and chronic liver disease (12.2%) as the most frequent underlying conditions. All patients recovered, with the mean time of viral nucleic acid clearance at 10.6 days. Chest CT scans presented ground-glass opacities in 53.7% of patients while 26.8% had normal CT images. Laboratory results showed that lymphocyte counts, lymphocyte percentages, ESR, CRP, IgG, Fib, and cytokines were correlated to patients’ conditions. Approximately 60–90% of patients had abnormally high levels of cytokines IL-4, IL-6, IL-10, and/or TNF-α. Conclusions: Our results showed variable clinical and laboratory presentations among this group of patients infected with the COVID-19 virus. Though all 41 patients recovered, our results suggest that cytokine levels and other biochemical indicators should be monitored for patients infected with the COVID-19 virus showing no to moderate symptoms to ensure quick access for critical medical attention, if needed.
【저자키워드】 COVID-19, Cytokines, Asymptomatic, close contact, epidemiogy, biochemical & physiological biomarkers, 【초록키워드】 Treatment, public health, IgG, pandemic, fatigue, Epidemiology, IL-6, COVID-19 pandemic, CRP, cytokine, Symptom, cough, hypertension, Symptoms, Laboratory, clinical manifestations, China, outcomes, lymphocyte, 2019 novel coronavirus, ground-glass opacity, Physical examination, CT scan, Fever, Wuhan, Patient, Clustering, COVID-19 virus, ESR, women, IL-10, information, underlying conditions, disease, Critical, moderate, patients, TNF-α, IL-4, chronic liver disease, demographics, biochemical, median age, clinical information, viral nucleic acid, percentages, lymphocyte counts, clearance, while, dominant, radiological, initial, investigated, Most patient, correlated, had no, analyses, conditions, the mean, cytokine level, laboratory result, retrieved, 【제목키워드】 China, clinical,