Background: Efficient healthcare based on prognostic variables in hospitalised patients with COVID-19 could reduce the risk of complications and death. Recently, soluble urokinase Plasminogen Activator Receptor (suPAR) was shown to predict respiratory failure, kidney injury, and clinical outcome in patients with SARS-CoV-2 infection. The aim of this study was to investigate the value of suPAR as a prognostic tool, in comparison with other variables, regarding disease severity and length of hospital stay in patients with COVID-19. Patients and Methods: Individuals hospitalised with COVID-19 (40 males, 20 females; median age 57.5 years) with a median symptom duration of 10 days and matched, healthy controls ( n = 30) were included. Admission levels of suPAR were measured in serum by enzyme-linked immunosorbent assay. Blood cell counts, C-reactive protein (CRP) levels, lactate dehydrogenase (LDH), plasma creatinine and estimated glomerular filtration rates were analysed and oxygen demand, level of care and length of hospitalisation recorded. Results: Patients had significantly higher suPAR levels compared to controls ( P < 0.001). Levels were higher in severely/critically (median 6.6 ng/mL) compared with moderately ill patients (median 5.0 ng/mL; P = 0.002). In addition, suPAR levels correlated with length of hospitalisation (rho = 0.35; P = 0.006). Besides suPAR, LDH, CRP, neutrophil count, neutrophil-to-monocyte and neutrophil-to-lymphocyte ratio, body mass index and chronic renal failure were discriminators of COVID-19 severity and/or predictors of length of hospitalisation. Conclusion: Admission levels of suPAR were higher in patients who developed severe/critical COVID-19 and associated with length of hospital stay. In addition, we showed that suPAR functioned as an independent predictor of COVID-19 disease severity.
【저자키워드】 COVID-19, Biomarker, Respiratory failure, disease severity, suPAR, Length of hospital stay, 【초록키워드】 Infection, COVID-19 severity, LDH, risk, CRP, oxygen, lactate dehydrogenase, Neutrophil-to-lymphocyte ratio, Kidney injury, Clinical outcome, serum, body mass index, healthcare, Patient, Control, death, Complication, plasma, predictor, prognostic, hospitalisation, Care, predict, efficient, glomerular filtration rate, creatinine, Hospital stay, blood cell, C-reactive protein (CRP, healthy control, median age, individual, plasminogen, neutrophil count, COVID-19 disease severity, activator, renal, hospitalised, males, independent, other variables, enzyme-linked immunosorbent, shown, addition, analysed, median, correlated, significantly higher, hospitalised patient, reduce, Level, recorded, were measured, ill patient, median symptom, patients with COVID-19, patients with SARS-CoV-2, prognostic variable, with COVID-19, 【제목키워드】 plasminogen, activator, urokinase, Length,