The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages that carry mutations in the spike gene are of concern for potential impact to treatment and prevention efforts. To monitor for new SARS-CoV-2 mutations, a panel of specimens were sequenced from both wave one (N = 96), and wave two (N = 117) of the pandemic in Senegal by whole genome next generation sequencing. Amongst these genomes, new combinations of SARS-CoV-2 spike mutations were identified, with E484K + N501T, L452R + N501Y, and L452M + S477N exclusively found in second wave specimens. These sequences are evidence of local diversification over the course of the pandemic and parallel evolution of escape mutations in different lineages.
【저자키워드】 Health care, Diseases, genetics, 【초록키워드】 Treatment, Evolution, SARS-CoV-2, coronavirus, pandemic, Mutation, Sequencing, mutations, Local, severe acute respiratory syndrome Coronavirus, L452R, spike gene, N501Y, Lineage, next generation sequencing, E484K, second wave, genomes, respiratory, lineages, specimens, escape mutation, SARS-CoV-2 spike, Evidence, Combination, evidence of, parallel evolution, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, sequence, specimen, S477N, whole genome, MONITOR, SARS-CoV-2 spike mutations, new SARS-CoV-2, Course, sequenced, 【제목키워드】 variant, Receptor binding domain, emergence, SARS-CoV-2 spike, Combination,