Background: Coronavirus disease (COVID-19) was first described at the end of 2019 in China and has since spread across the globe. Red cell distribution width (RDW) is a potent prognostic marker in several medical conditions and has recently been suggested to be of prognostic value in COVID-19. Methods: This retrospective, observational study of consecutive patients with COVID-19 was conducted from March 12, 2020 to December 4, 2020 in the Wilhelminenhospital, Vienna, Austria. RDWlevels on admission were collected and tested for their predictive value of 28-day mortality. Results: A total of 423 eligible patients with COVID-19 were included in the final analyses and 15.4% died within 28 days ( n = 65). Median levels of RDWwere significantly higher in non-survivors compared to survivors [14.6% (IQR, 13.7–16.3) vs. 13.4% (IQR, 12.7– 14.4), P < 0.001]. Increased RDW was a significant predictor of 28-day mortality [crude odds ratio (OR) 1.717, 95% confidence interval (CI) 1.462–2.017; P = < 0.001], independent of clinical confounders, comorbidities and established prognostic markers of COVID-19 (adjusted OR of the final model 1.368, 95% CI 1.126–1.662; P = 0.002). This association remained consistent upon sub-group analysis. Our study data also demonstrate that RDW levels upon admission for COVID-19 were similar to previously recorded, non-COVID-19 associated RDW levels [14.2% (IQR, 13.3–15.7) vs. 14.0% [IQR, 13.2–15.1]; P = 0.187]. Conclusions: In this population, RDWwas a significant, independent prognostic marker of short-term mortality in patients with COVID-19.
【저자키워드】 COVID-19, Prognosis, Red cell distribution width, pre-COVID-19, short-term mortality, 【초록키워드】 Mortality, 28-day mortality, Comorbidity, Spread, China, Vienna, Prognostic marker, distribution, disease, Admission, association, retrospective, Analysis, Odds ratio, Predictive, Non-COVID-19, Prognostic value, 95% CI, 95% confidence interval, confounders, Final, survivor, Cell, independent, non-survivor, tested, described, collected, globe, died, remained, conducted, adjusted, suggested, significantly higher, Increased, recorded, consecutive patient, eligible patient, IQR, medical condition, patients with COVID-19, Red, with COVID-19, 【제목키워드】 experience, width, Red,