Objective To analyze the application of lung ultrasound (LUS) diagnostic approach in obstetric patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and compare LUS score and symptoms of the patients. Design A single-center observational retrospective study from October 31, 2020 to March 31, 2021. Setting Department of Ob/Gyn at the University-Hospital of Udine, Italy. Participants Pregnant women with SARS-CoV-2 diagnosed with reverse transcription-PCR (RT-PCR) swab test were subdivided as symptomatic and asymptomatic patients with COVID-19. Exposure Lung ultrasound evaluation both through initial evaluation upon admission and through serial evaluations. Main Outcome Reporting LUS findings and LUS score characteristics. Results Symptomatic patients with COVID-19 showed a higher LUS (median 3.5 vs. 0, p < 0.001). LUS was significantly correlated with COVID-19 biomarkers as C-reactive protein (CPR; p = 0.011), interleukin-6 ( p = 0.013), and pro-adrenomedullin ( p = 0.02), and inversely related to arterial oxygen saturation ( p = 0.004). The most frequent ultrasound findings were focal B lines (14 vs. 2) and the light beam (9 vs. 0). Conclusion Lung ultrasound can help to manage pregnant women with SARS-CoV-2 infection during a pandemic surge. Study Registration ClinicalTrials.gov , NCT04823234. Registered on March 29, 2021.
【저자키워드】 COVID-19, SARS-CoV-2, pregnant women, Lung ultrasound, lung ultrasound score (LUS), 【초록키워드】 coronavirus, pandemic, Biomarker, SARS-COV-2 infection, Infection, diagnostic, interleukin-6, lung, C-reactive protein, Symptom, Italy, RT-PCR, reverse transcription-PCR, Registration, Retrospective study, oxygen saturation, Characteristics, Patient, Reporting, women, Swab test, Admission, patients, exposure, Obstetric, acute respiratory syndrome, help, single-center, participant, Department, approach, objective, setting, initial, Result, significantly, diagnosed, median, correlated, patients with COVID-19, symptomatic and asymptomatic, with COVID-19, 【제목키워드】 Ultrasound, clinical, SIGN,