T cell responses are a key cornerstone to viral immunity to drive high-quality antibody responses, establishing memory for recall and for viral clearance. Inefficient recruitment of T cell responses plays a role in the development of severe COVID-19 and is also represented by reduced cellular responses in men, children, and diversity compared with other epitope-specific subsets and available T cell receptor diversity. SARS-CoV-2-specific T cell responses are elicited by multiple vaccine formats and augmented by prior infection for hybrid immunity. Epitope conservation is relatively well-maintained leading to T cell crossreactivity for variants of concern that have diminished serological responses.
All Keywords
【저자키워드】 SARS-CoV-2, T cells, immunodominance, tetramer, T follicular cell, crossreactivity, 【초록키워드】 Vaccine, severe COVID-19, Immunity, antibody, children, Infection, variants of concern, viral clearance, memory, T cell, recall, recruitment, serological, T cell receptor, T cell response, cellular response, men, responses, reduced, elicited, subset, 【제목키워드】 targeting, Future, Against,
【저자키워드】 SARS-CoV-2, T cells, immunodominance, tetramer, T follicular cell, crossreactivity, 【초록키워드】 Vaccine, severe COVID-19, Immunity, antibody, children, Infection, variants of concern, viral clearance, memory, T cell, recall, recruitment, serological, T cell receptor, T cell response, cellular response, men, responses, reduced, elicited, subset, 【제목키워드】 targeting, Future, Against,