Background: Kidney transplant recipients appear to be at higher risk for critical COVID-19. Our analysis aimed to identify the possible risk factors for a severe course of the COVID-19 disease and to determine the influence of selected human leukocyte antigens (HLAs) on the course of the disease. Methods: This is a retrospective, multicenter analysis that included patients that were confirmed to be severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) positive after kidney transplantation (KT). The group of patients was divided into two subgroups according to the course of the infection, as follows: non-hospitalized and hospitalized. Results: A total of 186 patients (men, 69.4%) with confirmed SARS-CoV-2 positivity were included in the group. The following independent risk factors for the outcome of hospitalization were identified: the age at the time of infection [odds ratio (OR) = 1.19, P < 0.0001], a body mass index (BMI) >29.9 kg/m 2 (OR = 7.21, P < 0.0001), <7.5-mg prednisone dose/day (OR = 2.29, P = 0.0008), and HLA-DQ2 with a protective nature (OR = 0.05, P = 0.0034). Conclusions: Higher doses of corticosteroids (>7.5 mg/kg) in standard immunosuppressive regimes and HLA-DQ2 appear to be protective factors in our analysis.
【저자키워드】 COVID-19, Immunosuppression, Kidney transplantation, HLA class I and class II typing, steroid dose, 【초록키워드】 SARS-CoV-2, Hospitalized, Hospitalization, Infection, outcome, risk factor, Antigen, COVID-19 disease, kidney, body mass index, Patient, age, Prednisone, multicenter, BMI, Critical, Protective, Coronavirus-2, retrospective, Analysis, immunosuppressive, leukocyte, acute respiratory syndrome, higher risk, protective factor, SARS-CoV-2 positivity, independent risk factor, positive, recipient, men, Course, selected, identify, the disease, determine, doses of corticosteroid, two subgroup, 【제목키워드】 HLA, steroid, transplantation, role,