Background: Many patients who have been suffering by C ovid -19 suffer of long-C ovid syndrome, with symptoms of fatigue and muscular weakness that characterize post-acute sequelae SARS-CoV-2 infection (PASC). However, there is limited knowledge about the molecular pathophysiology, and about the serum profile of these patients. Methods: We studied the blood serum profile of 75 selected patients, with previous confirmed C ovid -19, 2 months after hospital discharge, who reported new-onset fatigue, muscle weakness and/or dyspnea not present prior to the virus infection and independently from concomitant diseases and/or clinical conditions. Results: All patients had very high serum concentrations of ferritin and D-Dimer. 87 and 72% of patients had clinically significant low levels of hemoglobin and albumin, respectively. Seventy three percentage had elevations in erythrocyte sedimentation rate and CRP. Twenty seven percentage had elevations in LDH. Conclusions: The co-existence of patient symptoms along with blood markers of coagulation, protein disarrangement and inflammation suggests ongoing alterations in the metabolism, promoting an inflammatory/hypercatabolic state which maintains a vicious circles implicated in the persistence of PASC. The persistence of altered D-Dimer levels raises the possibility of long-term risks of thromboembolic disease. All these markers levels should be accurately evaluated in the long-term follow-up, with individualized consideration for prophylactic nutritional, anti-inflammatory and/or anticoagulant therapy if indicated.
【저자키워드】 COVID-19, SARS-CoV2, rehabilitation, D-dimer, ferritin, Coagulation, PASC, Long-COVID-syndrome, 【초록키워드】 Inflammation, Anti-inflammatory, fatigue, knowledge, SARS-COV-2 infection, LDH, risk, CRP, Symptom, Prophylactic, metabolism, Protein, serum, pathophysiology, persistence, Dyspnea, Patient, albumin, hemoglobin, virus infection, molecular, patients, Blood, marker, Concentration, Long-term follow-up, anticoagulant therapy, erythrocyte sedimentation rate, alteration, thromboembolic disease, hospital discharge, syndrome, Elevation, weakness, clinical conditions, concomitant disease, Seven, raise, selected, reported, indicated, clinically, evaluated, maintain, implicated, muscular, patient symptom, 【제목키워드】 clinical, metabolic, profile,