Inactivated Sinovac-CoronaVac vaccine (Sinovac Life Sciences, Beijing) for coronavirus disease 2019 (COVID-19) has been used in many countries. However, its immunogenicity profile in immunosuppressed dermatological patients is lacking. This prospective observational case-control study compared the humoral immune response between adult dermatological patients receiving systemic immunosuppressive therapies ( n = 14) and those who did not ( n = 18); excluding patients with HIV infection, cancer, non-dermatological autoimmune conditions, previous COVID-19 infection, and positive anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG prior to vaccination. The subjects were advised to withhold methotrexate for 1 week after each vaccine dose while continuing other therapies unadjusted. Anti-SARS-CoV-2 IgG antibody, surrogate neutralizing antibody (sNAb), and seroconversion rates (calculated from the percentages of participants in the group with positive sNAb) were used to assess immunogenicity. We found that participants using azathioprine, cyclosporin, mycophenolate mofetil, or prednisolone ≥ 10 mg/day had a lower level of serum anti-SARS-CoV-2 IgG antibody and sNAb than those received methotrexate ≤ 10 mg/week, prednisolone < 10 mg/day, or biologics (i.e., secukinumab, ixekizumab, omalizumab). Patients who received methotrexate ≤ 10 mg/week, prednisolone < 10 mg/day or the biologics had a similar immunogenicity profile to those without immunosuppressive therapies. Despite the lack of statistical significance, a reduction of humoral immune response was observed among the study participants who used ≥2 immunosuppressants or pemphigus patients. Our findings suggest that a subset of patients with immune-mediated skin conditions respond poorly to the vaccine despite having low-level immunosuppression. These patients could benefit from vaccines that trigger a greater level of immunogenicity or booster doses.
【저자키워드】 immunogenicity, CoronaVac, Immunosuppression, Sinovac, Inactivated COVID-19 vaccine, autoimmune skin diseases, 【초록키워드】 COVID-19, coronavirus disease, neutralizing antibody, SARS-CoV-2, IgG, Vaccine, coronavirus, vaccination, therapy, antibody, Cancer, Infection, vaccine dose, serum, IgG antibody, COVID-19 infection, anti-SARS-CoV-2 IgG, Patient, humoral immune response, methotrexate, patients, immunosuppressive therapy, Immunosuppressant, case-control study, Immune-mediated, Immunosuppressed, Prednisolone, immunosuppressive therapies, reduction, booster doses, acute respiratory syndrome, subject, statistical significance, Beijing, participant, Sinovac Life Sciences, seroconversion rate, positive, autoimmune conditions, benefit, greater, lack, receiving, calculated, condition, were used, the vaccine, subset, study participant, patients with HIV, percentage, respond poorly, 【제목키워드】 COVID-19, response, Immunosuppressant,