Background: In this study, we investigated the relationship between serum lactate dehydrogenase (LDH) level and disease progression and prognosis of patients with COVID-19. Methods: We retrospectively reviewed the information of 1,751 patients with COVID-19 from Leishenshan Hospital in Wuhan, China. Univariate and multivariate Cox regression analyses as well as Logistics regression analyses, and Kaplan-Meier curves were used to determine the association between LDH levels and the prognosis of COVID-19 patients. Results: LDH was an independent risk factor for in-hospital death no matter it was taken as classified variable and continuous variable (all P = 0.001) but not for severe or critical illness status. The Kaplan-Meier curves for LDH level showed that an elevated level of LDH was associated with in-hospital death. Conclusions: In patients with COVID-19, the increased LDH level is associated with a higher risk of negative clinical prognosis and higher mortality. This will provide a reference for clinicians and researchers to understand, diagnose, and treat patients with COVID-19. Further prospective studies with larger sample sizes are needed to verify these findings.
【저자키워드】 COVID-19, SARS-CoV-2, Prognostic factor, lactate dehydrogenase (LDH), Leishenshan Hospital, 【초록키워드】 Mortality, Prognosis, Prospective Study, LDH, Disease progression, information, Critical, COVID-19 patients, diagnose, association, Analysis, In-hospital death, Regression analyses, Clinical prognosis, Sample size, higher risk, multivariate Cox regression, treat, Kaplan-Meier curve, independent risk factor, logistics, continuous variable, Wuhan, China, investigated, elevated, were used, determine, prognosis of patient, clinicians and researcher, patients with COVID-19, serum lactate, with COVID-19, 【제목키워드】 Factor, dehydrogenase, Sample, Level,