Background: Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome-Corona Virus 2 has generated significant impact on global health worldwide. COVID-19 can cause pneumonia and organ injury. Chronic kidney disease (CKD) has been associated with increased mortality in previous epidemics, but there is a paucity of data regarding actual risks for non-dialysis CKD patients with COVID-19. Methods: Multicenter, observational cohort study including 136 non-dialysis CKD patients and 136 age- and sex-matched controls that required hospitalization due to COVID-19. Patients with end-stage renal disease, a kidney transplant or without registered baseline glomerular filtration rate prior to COVID-19 infection were excluded. CKD and acute kidney injury (AKI) were defined according to KDIGO criteria. Results: CKD patients had higher white blood cell count and D-dimer and lower lymphocyte percentage. No differences were found regarding symptoms on admission. CKD was associated with higher rate of AKI (61 vs. 24.3%) and mortality (40.4 vs. 24.3%). Patients with AKI had the highest hazard for death (AKI/non-CKD HR:7.04, 95% CI:2.87–17.29; AKI/CKD HR:5.25, 95% CI: 2.29–12.02), followed by CKD subjects without AKI (HR:3.39, 95% CI:1.36–8.46). CKD status did not condition ICU admission or length of in-hospital stay. Conclusions: CKD patients that require hospitalization due to COVID-19 are exposed to higher risk of death and AKI.
【저자키워드】 Pneumonia, COVID−19, Acute kidney damage, renal failure, chornic kidney disease, 【초록키워드】 COVID-19, Coronavirus disease 2019, Mortality, Hospitalization, Epidemics, D-dimer, Acute kidney injury, Symptom, lymphocyte, Health, AKI, White blood cell, COVID-19 infection, Patient, ICU admission, Control, death, End-stage renal disease, Kidney disease, age, respiratory, Admission, kidney transplant, glomerular filtration rate, CKD, criteria, chronic, paucity of data, In-hospital, Observational cohort study, higher risk, subject, Registered, organ injury, increased mortality, KDIGO, defined, highest, caused, required, actual risk, baseline, patients with COVID-19, were excluded, 【제목키워드】 COVID-19, CKD,