Uric acid as a prognostic factor and critical marker of COVID-19

COVID-19의 예후 인자이자 중요한 마커인 요산

Published on
Journal: Scientific Reports
[저자] Gang Li, Xia Wu, Chen-liang Zhou, Ye-ming Wang, Bin Song, Xiao-bin Cheng, Qiu-fen Dong, Liu-lin Wang, Sha-sha You, Yuan-ming Ba
[Category] 바이오마커, 임상, 치료제,
PMC URL    [DOI] 10.1038/s41598-021-96983-4    
[Article Type] Observational Study
[Source] PMC

The purpose of this study is to explore whether uric acid (UA) can independently act as a prognostic factor and critical marker of the 2019 novel corona virus disease (COVID-19). A multicenter, retrospective, and observational study including 540 patients with confirmed COVID-19 was carried out at four designated hospitals in Wuhan. Demographic, clinical, laboratory data were collected and analyzed. The primary end point was in-hospital death of patients with COVID-19. The concentration of admission UA ( ad UA) and the lowest concentration of uric acid during hospitalization ( low UA) in the dead patients were significantly lower than those in the survivors. Multivariate logistic regression analysis showed the concentration of low UA (OR 0.986, 95% CI 0.980–0.992, p < 0.001) was able to independently predict the risk of in-hospital death. The mean survival time in the low-level group of low UA was significantly lower than other groups. When low UA was ≤ 166 µmol/L, the sensitivity and specificity in predicting hospital short-term mortality were 76.9%, (95% CI 68.5–85.1%) and 74.9% (95% CI 70.3–78.9%). This retrospective study determined that the lowest concentration of UA during hospitalization can be used as a prognostic indicator and a marker of disease severity in severe patients with COVID-19.

All Keywords
【저자키워드】 viral infection, Predictive markers, 【초록키워드】 COVID-19, Mortality, Hospitalization, disease severity, hospital, risk, observational study, Retrospective study, Survivors, Sensitivity and specificity, Wuhan, Patient, Severe patient, multicenter, demographic, disease, Admission, Critical, predict, novel corona virus, marker, retrospective, Concentration, Prognostic factor, Virus Disease, survival time, uric acid, the dead, In-hospital death, Logistic regression analysis, mean survival time, severe patients, 95% CI, laboratory data, multivariate, primary end point, multivariate logistic regression analysis, acid, dead patients, dead, significantly lower, prognostic indicator, lowest, analyzed, collected, carried, can be used, groups, dead patient, patients with COVID-19, with COVID-19, 【제목키워드】 COVID-19, Critical,
이 연구의 목적은 요산(UA)이 2019년 신종 코로나바이러스 감염증(COVID-19)의 예후 인자이자 중요한 마커로 독립적으로 작용할 수 있는지 여부를 조사하는 것입니다. 우한의 4개 지정 병원에서 코로나19 확진 환자 540명을 포함한 다기관, 후향적, 관찰 연구를 수행했다. 인구 통계, 임상, 실험실 데이터를 수집하고 분석했습니다. 1차 종료점은 코로나19 환자의 병원 내 사망이었다. 입원 중 UA 농도(ad UA)와 입원 중 최저 요산 농도(low UA)는 사망 환자에서 생존자보다 유의하게 낮았다. 다변량 로지스틱 회귀 분석에서는 낮은 UA 농도(OR 0.986, 95% CI 0.980–0.992, p < 0.001)가 병원 내 사망 위험을 독립적으로 예측할 수 있음을 보여주었습니다. 낮은 UA의 낮은 수준 그룹의 평균 생존 시간은 다른 그룹보다 유의하게 낮았습니다. 낮은 UA가       166 µmol/L일 때 병원 단기 사망률 예측의 민감도와 특이도는 76.9%, (95% CI 68.5-85.1%) 및 74.9% (95% CI 70.3-78.9%)였습니다. 이 후향적 연구는 입원 중 가장 낮은 UA 농도가 COVID-19 중증 환자의 예후 지표 및 질병 중증도의 지표로 사용될 수 있다고 결정했습니다.