Background: Coronavirus disease (COVID-19) has swept around the globe and led to a worldwide catastrophe. Studies examining the disease progression of patients with non-severe disease on admission are scarce but of profound importance in the early identification of patients at a high risk of deterioration. Objectives: To elucidate the differences in clinical characteristics between patients with progressive and non-progressive COVID-19 and to determine the risk factors for disease progression. Study design: Clinical data of 365 patients with non-severe COVID-19 from 1 January 2020 to 18 March 2020 were retrospectively collected. Patients were stratified into progressive and non-progressive disease groups. Univariate and multivariate logistic regression analyses were performed to determine the independent risk factors for disease progression. Results: Compared with patients with non-progressive disease, those who progressed to severe COVID-19 were older and had significantly decreased lymphocyte and eosinophil counts; increased neutrophil and platelet counts; lower albumin levels; higher levels of lactate dehydrogenase, C-reactive protein (CRP), creatinine, creatinine kinase, and urea nitrogen; and longer prothrombin times. Hypertension, fever, fatigue, anorexia, bacterial coinfection, bilateral patchy shadowing, antibiotic and corticosteroid administration, and oxygen support had a significantly higher incidence among patients with progressive disease. A significantly longer duration of hospital stay was also observed in patients with progressive disease. Bilateral patchy shadowing (OR = 4.82, 95% CI: 1.33–17.50; P = 0.017) and elevated levels of creatinine (OR =6.24, 95% CI: 1.42–27.40; P = 0.015), and CRP (OR = 7.28, 95% CI: 2.56–20.74; P < 0.001) were independent predictors for disease progression. Conclusion: The clinical characteristics of patients with progressive and non-progressive COVID-19 were significantly different. Bilateral patchy shadowing and increased levels of creatinine, and CRP were independent predictors of disease progression.
【저자키워드】 severe acute respiratory syndrome coronavirus 2, Coronavirus disease 2019, C-reactive protein, Disease progression, creatinine, creatinine kinase, bilateral patchy shadowing, 【초록키워드】 Corticosteroid, COVID-19, severe COVID-19, fatigue, Clinical characteristics, neutrophil, CRP, progression, risk factor, lactate dehydrogenase, eosinophil, lymphocyte, Deterioration, clinical, Fever, Patient, albumin, Platelet, incidence, disease, Admission, Bacterial, antibiotic, administration, Analysis, Hospital stay, high risk, urea, Older, anorexia, multivariate logistic regression, independent risk factor, progressive disease, oxygen support, performed, collected, globe, significantly, the disease, elevated, determine, significantly higher, groups, stratified, Bilateral, independent predictor, patchy, progressed, 【제목키워드】 China, clinical, Progressive,