Objectives: To analyze follow-up CTs of patients recovering from COVID-19 in Wuhan, focusing on fibrotic change and its relevant risk factors. Methods: From January 13 to February 27, 2020, 166 hospitalized patients meeting our criteria were included. The scores of fibrotic patterns on follow-up CT were evaluated. Patients were designated as group 1 (with CT evidence of fibrotic pattern) and group 2 (without CT evidence of fibrotic pattern). Multivariate logistic regression was performed to explore risk factors for fibrotic change in patients with COVID-19. Results: The follow-up CTs were obtained on 56 days (median, IQR 51–63 days) after symptom onset. Of the 166 patients (mean age, 57 ± 15 years; 69/166 male), 46% (76/166) had CT evidence of fibrotic change and 77% (127/166) were severe or critical cases. Among patients with fibrotic change on CT, 84% (64/76) got a minimal or mild score of fibrosis. The high total score on peak CT, peak eosinophils, erythrocyte sedimentation rate (ESR) and advancing age were related to lung fibrotic change in patients with COVID-19. Conclusion: Forty six percentages of patients (mainly severe or critical cases) with COVID-19 showed fibrotic change on follow-up CT at early recovery phase, while the extent of fibrosis was not large. The advancing age, high total score on peak CT, peak eosinophils and ESR were associated with fibrotic change depicted by CT in patients recovering from COVID-19. An extended follow up by CT imaging and pulmonary function testing is necessary to fully assess the sequela of COVID-19.
【저자키워드】 Risk factors, Follow-up, chest CT imaging, coronavirus disease 2019 (COVID- 19), fibrotic change, 【초록키워드】 COVID-19, lung, fibrosis, risk factor, eosinophil, eosinophils, Wuhan, male, Patient, Logistic regression, Mild, age, ESR, Evidence, critical cases, Pulmonary function testing, criteria, early recovery, symptom onset, erythrocyte sedimentation rate, multivariate, total score, evaluated, was performed, median, hospitalized patient, IQR, patients with COVID-19, percentage, recovering from COVID-19, with COVID-19, 【제목키워드】 COVID-19, change, experience,