Coronavirus disease 2019 (COVID-19) is spreading throughout the world. Limited data are available for the dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load (VL) in immunocompromised pediatric patients. Here, we report the clinical characteristics and the dynamics of SARS-CoV-2 VL of a pediatric patient with acute myeloid leukemia who developed a hyperinflammatory status mimicked MIS-C. The clinical course was characterized by the late onset of fever, GI symptoms, rash, and respiratory distress, including oxygen requirement with sustained VL of SARS-CoV-2 around 7 log 10 RNA copies/mL for 6 weeks. It is important to note that the hyperinflammatory status developed early at the third week of hospitalization—in a context of high VL and immunocompromised status. All these characteristics make this clinical case unique. On the other hand, while many reports have characterized the dynamics of SARS-CoV-2 VL in adults and immunocompetent hosts, it remains unreported in pediatrics—even less in immunosuppressed children.
【저자키워드】 COVID-19, SARS-CoV-2, pediatrics, Viral load, immunocompromised state, hyperinflammatory status, 【초록키워드】 Coronavirus disease 2019, coronavirus, Clinical characteristics, pediatric, children, MIS-C, RNA, Clinical course, Characteristics, Pediatric patients, Patient, Immunocompromised, Rash, leukemia, GI symptoms, distress, Immunosuppressed, acute respiratory syndrome, hosts, Oxygen requirement, immunocompromised status, log, onset of fever, characterized, less, unique, sustained, Limited, 【제목키워드】 Child, status, load,