Introduction: Given the ongoing coronavirus disease 2019 (COVID-19) pandemic and the consequent global healthcare crisis, there is an urgent need to better understand risk factors for symptom deterioration and mortality among patients with COVID-19. This systematic review aimed to meet the need by determining the predictive value of chronic diseases for COVID-19 severity and mortality. Methods: We searched PubMed, Embase, Web of Science, and Cumulative Index to Nursing and Allied Health Complete to identify studies published between December 1, 2019, and December 31, 2020. Two hundred and seventeen observational studies from 26 countries involving 624,986 patients were included. We assessed the risk of bias of the included studies and performed a cumulative meta-analysis. Results: We found that among COVID-19 patients, hypertension was a very common condition and was associated with higher severity, intensive care unit (ICU) admission, acute respiratory distress syndrome, and mortality. Chronic obstructive pulmonary disease was the strongest predictor for COVID-19 severity, admission to ICU, and mortality, while asthma was associated with a reduced risk of COVID-19 mortality. Patients with obesity were at a higher risk of experiencing severe symptoms of COVID-19 rather than mortality. Patients with cerebrovascular disease, chronic liver disease, chronic renal disease, or cancer were more likely to become severe COVID-19 cases and had a greater probability of mortality. Conclusions: COVID-19 patients with chronic diseases were more likely to experience severe symptoms and ICU admission and faced a higher risk of mortality. Aggressive strategies to combat the COVID-19 pandemic should target patients with chronic diseases as a priority.
【저자키워드】 COVID-19, Mortality, severity, systematic review, Chronic diseases, cumulative meta-analysis, 【초록키워드】 coronavirus disease, Meta-analysis, Asthma, pandemic, intensive care, severe COVID-19, COVID-19 pandemic, obesity, Cancer, COVID-19 severity, Symptom, risk factor, hypertension, observational study, chronic disease, ICU, Probability, Deterioration, Patient, ICU admission, Nursing, Admission, COVID-19 patients, pulmonary disease, acute respiratory distress, COVID-19 mortality, chronic liver disease, Cerebrovascular disease, COVID-19 patient, chronic, Predictive, index, Web of Science, higher risk, reduced risk, syndrome, chronic renal disease, cumulative, global healthcare, Obstructive, country, greater, identify, performed, searched, severe symptom, Aggressive, patients with COVID-19, risk of bia, 【제목키워드】 review, chronic,