There is increasing evidence of gastrointestinal (GI) infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We surveyed the co-expression of SARS-CoV-2 entry genes ACE2 and TMPRSS2 throughout the GI tract to assess potential sites of infection. Publicly available and in-house single-cell RNA-sequencing datasets from the GI tract were queried. Enterocytes from the small intestine and colonocytes showed the highest proportions of cells co-expressing ACE2 and TMPRSS2 . Therefore, the lower GI tract represents the most likely site of SARS-CoV-2 entry leading to GI infection.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, scRNA-seq, gastrointestinal tract, 【초록키워드】 ACE2, TMPRSS2, coronavirus, Infection, dataset, GI Tract, Evidence, acute respiratory syndrome, SARS-CoV-2 entry, small intestine, Single-cell RNA-sequencing, co-expression, Cell, highest, proportion, Enterocyte, 【제목키워드】 Gastrointestinal, abundance, relative, Lower, tract, Enterocyte,
【저자키워드】 COVID-19, SARS-CoV-2, scRNA-seq, gastrointestinal tract, 【초록키워드】 ACE2, TMPRSS2, coronavirus, Infection, dataset, GI Tract, Evidence, acute respiratory syndrome, SARS-CoV-2 entry, small intestine, Single-cell RNA-sequencing, co-expression, Cell, highest, proportion, Enterocyte, 【제목키워드】 Gastrointestinal, abundance, relative, Lower, tract, Enterocyte,