Prognostic markers are needed to understand the disease course and severity in patients with Covid-19. There is evidence that Covid-19 causes gastrointestinal symptoms and abnormalities in liver enzymes. We aimed to determine if hepatobiliary laboratory data could predict disease severity in patients with Covid-19. In this retrospective, single institution, cohort study that analyzed patients admitted to a community academic hospital with the diagnosis of Covid-19, we found that elevations of Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) and Alkaline Phosphatase (AP) at any time during hospital admission increased the odds of ICU admission by 5.12 (95% CI: 1.55–16.89; p = 0.007), 4.71 (95% CI: 1.51–14.69; p = 0.01) and 4.12 (95% CI: 1.21–14.06, p = 0.02), respectively. Hypoalbuminemia found at the time of admission to the hospital was associated with increased mortality ( p = 0.02), hypotension ( p = 0.03), and need for vasopressors ( p = 0.02), intubation ( p = 0.01) and hemodialysis ( p = 0.002). Additionally, there was evidence of liver injury: AST was significantly elevated above baseline in patients admitted to the ICU (54.2 ± 15.70 U/L) relative to those who were not (9.2 ± 4.89 U/L; p = 0.01). Taken together, this study found that hypoalbuminemia and abnormalities in hepatobiliary laboratory data may be prognostic factors for disease severity in patients admitted to the hospital with Covid-19.
【저자키워드】 Medical research, gastroenterology, 【초록키워드】 severity, disease severity, hospital, Diagnosis, intubation, Prognostic markers, ICU, cohort study, Hemodialysis, Hypotension, Patient, ICU admission, Community, Aspartate aminotransferase, Liver injury, Prognostic factors, AST, Hospital admission, Admission, liver, predict, marker, ALT, Evidence, retrospective, liver enzymes, gastrointestinal symptoms, Prognostic factor, Hypoalbuminemia, evidence of, alanine aminotransferase, phosphatase, alkaline phosphatase, Vasopressor, 95% CI, laboratory data, disease course, aspartate, Elevation, Alanine, vasopressors, Abnormalities, increased mortality, elevations, abnormality, Gastrointestinal symptom, Aminotransferase, Course, analyzed, significantly, the disease, elevated, determine, cause, baseline, 【제목키워드】 Prognostic factor, transaminase,