Autophagy is an intracellular degradation and recycling process that can also remove pathogenic intracellular bacteria and viruses from within cells (referred to as xenophagy) and activate the adaptive immune responses. But autophagy—especially Atg proteins including Atg8 family members—can also have proviral and probacterial effects. In this review, we summarize known interactions of bacterial, parasitic, and viral proteins with Atg8 family proteins and the outcome of these interactions on pathogen replication, autophagy, or mitophagy. We discuss the value of prediction software and the research methodology in the study of pathogen protein‐Atg8 family protein interactions, with selected examples of potential LC3‐interacting region motif‐containing SARS‐CoV‐2 proteins. A possible workflow for the interaction analysis of pathogen proteins and Atg8 family proteins. In this review, we discuss recent advances in the field, the value of prediction software and the research methodology in the study of pathogen‐Atg8 family protein interactions, with selected examples of potential LC3‐interacting region motif containing SARS‐CoV‐2 proteins.
【저자키워드】 SARS‐CoV‐2, LC3, GABARAP, hfAIM, iLIR, LIR motif, 【초록키워드】 Proteins, outcome, autophagy, Replication, Protein, pathogen, Research, Bacteria, methodology, Degradation, Bacterial, Interaction, Analysis, adaptive immune responses, Viral protein, pathogenic, protein interactions, motif, SARS‐CoV‐2 proteins, Effects, Cell, selected, virus, example, activate, pathogen protein, 【제목키워드】 pathogen, Interaction,