A review of nasal sprays and gargles with antiviral properties suggests that a number of commonly used antiseptics including povidone-iodine, Listerine ® , iota-carrageenan and chlorhexidine should be studied in clinical trials to mitigate both the progression and transmission of SARS-CoV-2. Several of these antiseptics have demonstrated the ability to cut the viral load of SARS-CoV-2 by 3–4 log 10 in 15–30 s in vitro . In addition, hypertonic saline targets viral replication by increasing hypochlorous acid inside the cell. A number of clinical trials are in process to study these interventions both for prevention of transmission, prophylaxis after exposure, and to diminish progression by reduction of viral load in the early stages of infection. Tweetable abstract Commonly used antiseptics including povidone-iodine, Listerine ® , iota-carrageenan and chlorhexidine should be studied in clinical trials to mitigate the progression and transmission of SARS-CoV-2.
【저자키워드】 COVID-19, respiratory infections, SARS-CoV-2, Nasal spray, hypertonic saline, iota-carrageenan, chlorhexidine, povidone-iodine, hydrogen peroxide, oral rinse, 【초록키워드】 clinical trial, Infection, Intervention, Transmission, nasal, progression, in vitro, Prophylaxis, Viral load, viral replication, target, early stage, antiviral property, reduction, Abstract, transmission of SARS-CoV-2, mitigate, Cell, log, addition, demonstrated, hypertonic, Listerine, 【제목키워드】 review, nasal, global pandemic,