The COVID-19 pandemic has become a priority in the health systems of all nations worldwide. In fact, there are currently no specific drugs or preventive treatments such as vaccines. The numerous therapies available today aim to counteract the symptoms caused by the viral infection that in some subjects can evolve causing acute respiratory distress syndromes (ARDS) with consequent admission to intensive care unit. The exacerbated response of the immune system, through cytokine storm, causes extensive damage to the lung tissue, with the formation of edema, fibrotic tissues and susceptibility to opportunistic infections. The inflammatory picture is also aggravated by disseminated intravascular coagulation which worsens the damage not only to the respiratory system, but also to other organs. In this context, perinatal cells represent a valid strategy thanks to their strong immunomodulatory potential, their safety profile, the ability to reduce fibrosis and stimulate reparative processes. Furthermore, perinatal cells exert antibacterial and antiviral actions. This review therefore provides an overview of the characteristics of perinatal cells with a particular focus on the beneficial effects that they could have in patients with COVID-19, and more specifically for their potential use in the treatment of ARDS and sepsis.
【저자키워드】 Mesenchymal stromal cells, Perinatal, placental expanded, coronavirus-induced disease 2019, severe acute respiratory distress syndrome coronavirus-2, 【초록키워드】 Treatment, viral infection, ARDS, Cytokine storm, therapy, intensive care, Antiviral, Vaccines, susceptibility, COVID-19 pandemic, fibrosis, Sepsis, Symptom, drug, immune system, Characteristics, immunomodulatory, edema, Respiratory system, health system, Admission, safety profile, opportunistic Infections, acute respiratory distress, Disseminated intravascular coagulation, Inflammatory, tissue, subject, syndrome, other organs, lung tissue, exacerbated response, Effect, Cell, caused, provide, cause, reduce, stimulate, patients with COVID-19, 【제목키워드】 COVID-19,