The coronavirus disease (COVID-19) pandemic is caused by a novel coronavirus (CoV) named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As the angiotensin converting enzyme 2 (ACE2) is the cellular receptor of SARS-CoV-2, it has a strong interaction with the renin angiotensin system (RAS). Experimental studies have shown that the higher levels of ACE2 or increasing ACE2/ACE1 ratio improve COVID-19 outcomes through lowering inflammation and death. Aerobic moderate intensity physical exercise fights off infections by two mechanisms, the inhibition of ACE/Ang II/AT1-R pathway and the stimulation of ACE2/Ang-(1–7)/MasR axis. Exercise can also activate the anti-inflammatory response so that it can be a potential therapeutic strategy against COVID-19. Here, we summarize and focus the relation among COVID-19, RAS, and immune system and describe the potential effect of aerobic moderate intensity physical exercise against CoV as a useful complementary tool for providing immune protection against SARS-CoV-2 virus infection, which is a novel intervention that requires further investigation.
【저자키워드】 SARS-CoV-2, Inflammation, coronavirus, renin angiotensin system, immune protection, 【초록키워드】 COVID-19, coronavirus disease, exercise, ACE2, pandemic, Infection, Intervention, immune system, outcome, RAS, Novel coronavirus, death, pathway, CoV, mechanisms, moderate, therapeutic strategy, Interaction, complementary, intensity, acute respiratory syndrome, enzyme, anti-inflammatory response, SARS-CoV-2 virus infection, cellular receptor, aerobic, physical, IMPROVE, shown, caused, activate, 【제목키워드】 exercise, Effect, System, role, Potential, Against,