SARS-CoV-2 virus causes infection which led to a global pandemic in 2020 with the development of severe acute respiratory syndrome. Therefore, this study was aimed at examining its possible role in predicting severity and intrahospital mortality of COVID-19, alongside with other laboratory and biochemical procedures, clinical signs, symptoms, and comorbidity. This study, approved by the Ethical Committee of Clinical Center Kragujevac, was designed as an observational prospective cross-sectional clinical study which was conducted on 127 patients with diagnosed respiratory COVID-19 viral infection from April to August 2020. The primary goals were to determine the predictors of COVID-19 severity and to determine the predictors of the negative outcome of COVID-19 infection. All patients were divided into three categories: patients with a mild form, moderate form, and severe form of COVID-19 infection. All biochemical and laboratory procedures were done on the first day of the hospital admission. Respiratory ( p < 0.001) and heart ( p = 0.002) rates at admission were significantly higher in patients with a severe form of COVID-19. From all observed hematological and inflammatory markers, only white blood cell count (9.43 ± 4.62, p = 0.001) and LDH (643.13 ± 313.3, p = 0.002) were significantly higher in the severe COVID-19 group. We have observed that in the severe form of SARS-CoV-2, the levels of superoxide anion radicals were substantially higher than those in two other groups (11.3 ± 5.66, p < 0.001) and the nitric oxide level was significantly lower in patients with the severe disease (2.66 ± 0.45, p < 0.001). Using a linear regression model, TA, anosmia, ageusia, O 2 − , and the duration at the ICU are estimated as predictors of severity of SARS-CoV-2 disease. The presence of dyspnea and a higher heart rate were confirmed as predictors of a negative, fatal outcome. Results from our study show that presence of hypertension, anosmia, and ageusia, as well as the duration of ICU stay, and serum levels of O 2 − are predictors of COVID-19 severity, while the presence of dyspnea and an increased heart rate on admission were predictors of COVID-19 mortality.
【초록키워드】 COVID-19, SARS-CoV-2, viral infection, Mortality, severe COVID-19, nitric oxide, cross-sectional, severity, Infection, inflammatory markers, COVID-19 severity, LDH, Comorbidity, SARS-CoV-2 virus, outcome, hypertension, Symptoms, ICU, Anosmia, Laboratory, global pandemic, Severe acute respiratory syndrome, Viral, Ageusia, White blood cell, COVID-19 infection, Dyspnea, Patient, Mild, Clinical signs, Hospital admission, predictor, heart rate, respiratory, group, Admission, moderate, clinical study, COVID-19 mortality, severe disease, blood cell, on admission, Superoxide, SARS-CoV-2 disease, acute respiratory syndrome, laboratory procedures, biochemical, Serum level, serum levels, white blood cell count, Clinical Center, hematological, ethical committee, significantly lower, Linear regression model, Committee, Result, diagnosed, approved, conducted, determine, significantly higher, cause, Clinical Center Kragujevac, 【제목키워드】 role,